Born as Trần Thị Thúy Loan on June 2, 1988 in Ho Chi Minh City, Vietnam, she grew up in a family of three children. Since her early childhood, she had been given the nickname, Lona. At the age of 12, her parents enrolled her at Suối Nhạc Music Academy in Ho Chi Minh City where she would study vocals and piano for two years. During her adolescence, Bảo Thy participated in various youth music troupes such as Sao Băng, Blue stars, SBS and Angels with minor success. At the age of 18, Bảo Thy would finally reach national prominence through the internet when she was voted as one of the ten most beautiful young women in a poll known as Võ Lâm Truyền Kỳ conducted through the website, VinaGame (now renamed as VNG.com). Bảo Thy along with Hải Yến had tied for the highest total number of votes and were both offered parts in the film by the same name produced by Phước Sang starring Đan Trường, Kim Thư, Chi Bảo, Hoài Linh and Vũ Thu Phương. Unfortunately, due to schedule conflicts and certain matters involving production, neither Bảo Thy nor Hải Yến were featured in the film which ended up being released two years later. Immediately after Võ Lâm Truyền Kỳ, Bảo Thy was voted again on another internet poll known as Miss Audition as one of the ten most beautiful young women of Vietnam. At the Miss Audition event held in Hanoi during the summer of that same year, Bảo Thy dazzled the audience with her duet performances with singer Vương Khang of the songs, 10 Minutes and Please Tell Me Why in Vietnamese lyrics in which she had also written. Toward the end of 2007, Bảo Thy accepted an offer to host an online music video program, Hành Trình Âm Nhạc. She would then go on to become the hostess of many other internet gameshows and music video programs in Vietnam such as Nào Ta Cùng Hát, Hành Trình Kết Nối Những Trái Tim and Album Vàng. Bảo Thy's face had also been chosen to grace the home screen pages on the Eee PC mini laptop manufactured by ASUS, Samsung wireless phone and Rexona.
Prior to the release of her duet studio album recorded with singer Quang Vinh, Ngôi Nhà Hoa Hồng (2008), Bảo Thy had enjoyed a series of successful hit singles released by Bến Thành Audio particularly with Công Chúa Bong Bóng (Bubble Gum Princess), the song often credited for having launched her singing career. On her 20th birthday, she performed to a sold-out intimate audience of 400 in a live concert show held in Ho Chi Minh City entitled as Balloon Party. Two months later, Bảo Thy's debut solo studio album, Có Bao Giờ... Em Sai, was released by the record label, Saigon Media. While recording Có Bao Giờ... Em Sai, Bảo Thy was offered the lead role in a feature film called Nữ Sinh Quý Tộc, which was to be directed by Lê Hoàng for Thiên Ngân Film Studios. Unfortunately, just days prior to principal shooting, the project ended up being shelved.
Yến Trang, Hoài Linh, Tấn Beo, Chí Tài, Khổng Tú Quỳnh and Đông Nhi. Bảo Thy recorded five songs for the film's soundtrack. For her acting debut on Vietnam's silver screen, Bảo Thy was honored with a Cánh Diều Vàng (Golden Kite Award) for Most Promising Newcomer.
For her sophomore effort, Bảo Thy scored another tremendous success with Ký Ức Của Mưa (2010). This album would earn her 3 Zing Music Awards. More than a year would pass before she would release her next studio album entitled as Special Album on November of 2011. In 2012, she starred in her second feature film, Gia Sư Nữ Quái, alongside Trấn Thành, Chí Tài, Hoài Linh and Dương Cẩm Lynh. On December of 2014, Bảo Thy returned with a live show performance, Tôi Tỏa Sáng, in Ho Chi Minh City with singer Cao Thái Sơn and also released a music video of a song she had written, Single Lady. In 2015, she recorded the Vietnamese version of the theme song to the Hong Kong drama thriller film, Line Walker, entitled as Càng Khó Càng Yêu, and released the music video to her single, I'm Sorry, Babe, in which she had written the lyrics, herself. In 2016, Bảo Thy recorded, wrote and released three more singles, Con Tim Anh Nằm Đâu, Lonely and Quay Lưng Đi. Bảo Thy has also recorded duets with singers Đăng Khôi, Bùi Anh Tuấn, Isaac, Only C, Dương Triệu Vũ and Lam Trường.
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